Reactome | WAC [nucleoplasm]

WAC [nucleoplasm]

Stable Identifier

R-HSA-8942150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WW domain-containing adapter protein with coiled-coil, WAC_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8WWB3 DYDC1

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External Reference Information

External Reference

UniProt:Q9BTA9 WAC

Gene Names

WAC, KIAA1844

Chain

chain:1-647

Reference Genes

BioGPS Gene:51322 WAC

COSMIC (genes):WAC WAC

CTD Gene:51322 WAC

dbSNP Gene:51322 WAC

ENSEMBL:ENSG00000095787 WAC

HGNC:17327 WAC

KEGG:hsa:51322 WAC

Monarch:51322 WAC

NCBI Gene:51322 WAC

OMIM:615049 WAC

UCSC:Q9BTA9 WAC

Reference Transcript

Participates

as an output of

RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)

as a component of

PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)

as an input of

RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)

Inferred To

wac-1.1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of WAC [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of WAC [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of WAC [nucleoplasm] (Schizosaccharomyces pombe)

Wac [nucleoplasm] (Mus musculus)

Wac [nucleoplasm] (Rattus norvegicus)

waca [nucleoplasm] (Danio rerio)

wac [nucleoplasm] (Xenopus tropicalis)

wcy [nucleoplasm] (Drosophila melanogaster)

WAC [nucleoplasm] (Bos taurus)

WAC [nucleoplasm] (Canis familiaris)

WAC [nucleoplasm] (Gallus gallus)

WAC [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000095787

ENSEMBL

ENSP00000311106, ENSP00000415727, ENST00000442148, ENSG00000095787, ENSP00000364816, ENSP00000506624, ENST00000679398, ENST00000439676, ENSP00000346986, ENST00000347934, ENSP00000506445, ENST00000354911, ENST00000375664, ENST00000679428, ENSP00000400848

HPA

ENSG00000095787-WAC

GeneCards

WAC

PRO

Q9BTA9

Pharos - Targets

Q9BTA9

Orphanet

WAC

GlyGen

Q9BTA9

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.666	4
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q99996-2 AKAP9			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.556	3
UniProt:Q8WWB3 DYDC1			0.556	3
UniProt:Q8TDW5 SYTL5			0.556	3
IntAct:EBI-10171556 147700			0.556	3
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.527	2
UniProt:O75150 RNF40	1	RNF40 [nucleoplasm] (R-HSA-5689015)	0.527	3

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