Reactome: A Curated Pathway Database

FOLR2 transports FOLA from extracellular region to cytosol

Stable Identifier
R-HSA-8942344
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The folate receptor beta (FOLR2, FBP) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). After ligand binding, the resultant complex is endocytosed into the cell where ligand release occurs in the acidic environment of the recycling endosome (Wibowo et al. 2013). For simplicity, the overall transport of FOLA from the extracellular region to the cytosol of a cell is described here.

Literature References
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Orthologous Events