FOLR2 transports FOLA from extracellular region to cytosol

Stable Identifier
R-HSA-8942344
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

The folate receptor beta (FOLR2, FBP) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). After ligand binding, the resultant complex is endocytosed into the cell where ligand release occurs in the acidic environment of the recycling endosome (Wibowo et al. 2013). For simplicity, the overall transport of FOLA from the extracellular region to the cytosol of a cell is described here.

Literature References
PubMed ID Title Journal Year
23934049 Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

Wibowo, AS, Singh, M, Reeder, KM, Carter, JJ, Kovach, AR, Meng, W, Ratnam, M, Zhang, F, Dann, CE

Proc. Natl. Acad. Sci. U.S.A. 2013
4066659 Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells

Antony, AC, Kane, MA, Portillo, RM, Elwood, PC, Kolhouse, JF

J. Biol. Chem. 1985
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