N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

Stable Identifier
R-HSA-8942575
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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N-Acetylaspartylglutamate (NAAG) is found at high concentrations in the vertebrate nervous system. It is an agonist of group II metabotropic glutamate receptors. A number of other functions have been proposed for NAAG, including a role as a non-excitotoxic transport form of glutamate and a molecular water pump (Lodder-Gadaczek et al. 2011, Neale et al. 2011). NAAG is synthesized by N-acetylaspartylglutamate synthase A (RIMKLA, NAAG synthetase A) and Beta-citrylglutamate synthase B (RIMKLB, NAAG synthetase B), which more efficiently catalyzes the synthesis of beta-citryl-L-glutamate (Collard et al. 2010, Lodder-Gadaczek et al. 2011).
Literature References
PubMed ID Title Journal Year
20657015 Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase

Lambert, DM, Stroobant, V, Kapanda, CN, Muccioli, GG, Opperdoes, F, Van Schaftingen, E, Lamosa, P, Collard, F, Poupaert, JH

J. Biol. Chem. 2010
Participants
Participates
Catalyst Activity

N-acetyl-L-aspartate-L-glutamate ligase activity of RIMKLA, RIMKLB [cytosol]

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