SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

Stable Identifier
R-HSA-8943007
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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At stalled replication forks, the E3 ubiquitin ligase SHPRH interacts with PCNA monoubiquitinated at lysine-164 (monoUb-K164-PCNA), the RAD18:UBE2B complex (RAD18:RAD6 complex), and the Ub:UBE2N:UBE2V2 complex (UBC13:MMS2 complex with ubiquitin conjugated to UBC13) (Unk et al. 2006, Motegi et al. 2006, Motegi et al. 2008).

Literature References
PubMed ID Title Journal Year
17108083 Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

Unk, I, Hajdu, I, Fatyol, K, Szakál, B, Blastyák, A, Bermudez, V, Hurwitz, J, Prakash, L, Prakash, S, Haracska, L

Proc. Natl. Acad. Sci. U.S.A. 2006
18719106 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

Motegi, A, Liaw, HJ, Lee, KY, Roest, HP, Maas, A, Wu, X, Moinova, H, Markowitz, SD, Ding, H, Hoeijmakers, JH, Myung, K

Proc. Natl. Acad. Sci. U.S.A. 2008
17130289 Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

Motegi, A, Sood, R, Moinova, H, Markowitz, SD, Liu, PP, Myung, K

J. Cell Biol. 2006
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