HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

Stable Identifier
R-HSA-8943041
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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At stalled replication forks, the E3 ubiquitin ligase HLTF interacts with PCNA monoubiquitinated at lysine-164 (monoUb-K164-PCNA), the RAD18:UBE2B complex (RAD18:RAD6 complex), and the Ub:UBE2N:UBE2V2 complex (UBC13:MMS2 complex with ubiquitin conjugated to UBC13) (Unk et al. 2008, Motegi et al. 2008, MacKay et al. 2009).

Literature References
PubMed ID Title Journal Year
19723507 Biochemical characterisation of the SWI/SNF family member HLTF

MacKay, C, Toth, R, Rouse, J

Biochem. Biophys. Res. Commun. 2009
18719106 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

Motegi, A, Liaw, HJ, Lee, KY, Roest, HP, Maas, A, Wu, X, Moinova, H, Markowitz, SD, Ding, H, Hoeijmakers, JH, Myung, K

Proc. Natl. Acad. Sci. U.S.A. 2008
18316726 Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

Unk, I, Hajdu, I, Fatyol, K, Hurwitz, J, Yoon, JH, Prakash, L, Prakash, S, Haracska, L

Proc. Natl. Acad. Sci. U.S.A. 2008
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