US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP

Stable Identifier
R-HSA-8943083
Type
Reaction
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
Locations in the PathwayBrowser
Summation

The human cytomegalovirus US11 protein interacts with a MHC class I heavy chain and recruits the heavy chain to the TMEM129 E3 ubiquitin ligase complex comprising TMEM129, its cognate E2 conjugases UBE2J2 and UBE2K and the VCP complex (VCP:VIMP) via the rhomboid pseudo-protease DERL1 (van de Weijer et al. 2014, van den Boomen et al. 2014, Flierman 2006, Lilley et al. 2004, Ye et al. 2004, Ye et al. 2001).

Literature References
PubMed ID Title Journal Year
15215855 A membrane protein required for dislocation of misfolded proteins from the ER

Lilley, BN, Ploegh, HL

Nature 2004
25030448 TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

van den Boomen, DJ, Timms, RT, Grice, GL, Stagg, HR, Skødt, K, Dougan, G, Nathan, JA, Lehner, PJ

Proc. Natl. Acad. Sci. U.S.A. 2014
16868077 E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system

Flierman, D, Coleman, CS, Pickart, CM, Rapoport, TA, Chau, V

Proc. Natl. Acad. Sci. U.S.A. 2006
24807418 A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

van de Weijer, ML, Bassik, MC, Luteijn, RD, Voorburg, CM, Lohuis, MA, Kremmer, E, Hoeben, RC, Leproust, EM, Chen, S, Hoelen, H, Ressing, ME, Patena, W, Weissman, JS, McManus, MT, Wiertz, EJ, Lebbink, RJ

Nat Commun 2014
11740563 The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

Ye, Y, Meyer, HH, Rapoport, TA

Nature 2001
15215856 A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

Ye, Y, Shibata, Y, Yun, C, Ron, D, Rapoport, TA

Nature 2004
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