Regulation of PTEN mRNA translation

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Homo sapiens
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MicroRNAs miR-17, miR-19a, miR-19b, miR-20a, miR-20b, miR-21, miR-22, miR-25, miR 26A1, miR 26A2, miR-93, miR-106a, miR-106b, miR 205, and miR 214 and bind PTEN mRNA and inhibit its translation into protein. These microRNAs are altered in cancer and can account for changes in PTEN levels. There is evidence that PTEN mRNA translation is also inhibited by other microRNAs, such as miR-302 and miR-26B, and these microRNAs will be annotated when additional experimental details become available (Meng et al. 2007, Xiao et al. 2008, Yang et al. 2008, Huse et al. 2009, Kim et al. 2010, Poliseno, Salmena, Riccardi et al. 2010, Zhang et al. 2010, Tay et al. 2011, Qu et al. 2012, Cai et al. 2013). In addition, coding and non coding RNAs can prevent microRNAs from binding to PTEN mRNA. These RNAs are termed competing endogenous RNAs or ceRNAs. Transcripts of the pseudogene PTENP1 and mRNAs transcribed from SERINC1, VAPA and CNOT6L genes exhibit this activity (Poliseno, Salmena, Zhang et al. 2010, Tay et al. 2011, Tay et al. 2014).

Literature References
PubMed ID Title Journal Year
20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Poliseno, L, Salmena, L, Riccardi, L, Fornari, A, Song, MS, Hobbs, RM, Sportoletti, P, Varmeh, S, Egia, A, Fedele, G, Rameh, L, Loda, M, Pandolfi, PP

Sci Signal 2010
23856247 miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer

Cai, J, Fang, L, Huang, Y, Li, R, Yuan, J, Yang, Y, Zhu, X, Chen, B, Wu, J, Li, M

Cancer Res. 2013
18199536 MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

Yang, H, Kong, W, He, L, Zhao, JJ, O'Donnell, JD, Wang, J, Wenham, RM, Coppola, D, Kruk, PA, Nicosia, SV, Cheng, JQ

Cancer Res. 2008
22000013 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Tay, Y, Kats, L, Salmena, L, Weiss, D, Tan, SM, Ala, U, Karreth, F, Poliseno, L, Provero, P, Di Cunto, F, Lieberman, J, Rigoutsos, I, Pandolfi, PP

Cell 2011
20080666 Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

Kim, H, Huang, W, Jiang, X, Pennicooke, B, Park, PJ, Johnson, MD

Proc. Natl. Acad. Sci. U.S.A. 2010
19487573 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

Huse, JT, Brennan, C, Hambardzumyan, D, Wee, B, Pena, J, Rouhanifard, SH, Sohn-Lee, C, le Sage, C, Agami, R, Tuschl, T, Holland, EC

Genes Dev. 2009
18327259 Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

Xiao, C, Srinivasan, L, Calado, DP, Patterson, HC, Zhang, B, Wang, J, Henderson, JM, Kutok, JL, Rajewsky, K

Nat. Immunol. 2008
20223231 MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

Zhang, JG, Wang, JJ, Zhao, F, Liu, Q, Jiang, K, Yang, GH

Clin. Chim. Acta 2010
24429633 The multilayered complexity of ceRNA crosstalk and competition

Tay, Y, Rinn, J, Pandolfi, PP

Nature 2014
17681183 MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

Meng, F, Henson, R, Wehbe-Janek, H, Ghoshal, K, Jacob, ST, Patel, T

Gastroenterology 2007
22374676 MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN

Qu, C, Liang, Z, Huang, J, Zhao, R, Su, C, Wang, S, Wang, X, Zhang, R, Lee, MH, Yang, H

Cell Cycle 2012
20577206 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Poliseno, L, Salmena, L, Zhang, J, Carver, B, Haveman, WJ, Pandolfi, PP

Nature 2010
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