Activated PPARG binds PTEN gene promoter

Stable Identifier
R-HSA-8944099
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Activated PPARG binds PTEN gene promoter
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The nuclear receptor PPARG (PPARgamma), activated by ligand binding, binds to peroxisome proliferator response elements (PPREs) in the promoter of the PTEN gene to activate PTEN transcription. It has not been tested whether nuclear receptors that heterodimerize with PPARG are involved in transcriptional regulation of PTEN (Patel et al. 2001).
Literature References
PubMed ID Title Journal Year
11378386 Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN

Downes, CP, Patel, L, MacPhee, CH, Coxon, P, Pass, I, Smith, SA

Curr. Biol. 2001
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Authored
Salmena, L  (2016-08-11)
Orlic-Milacic, M  (2016-11-02)
Carracedo, A  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-02)
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