miR-214 microRNA binds PTEN mRNA

Stable Identifier
R-HSA-8944650
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
miR-214 microRNA binds PTEN mRNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MicroRNA miR-214-3p, one of the two mature products of miR-214, binds to the 3'UTR of the PTEN mRNA and inhibits PTEN mRNA translation. As miR-214 reduces PTEN protein levels but not PTEN mRNA levels, miR-214 presumably functions as part of the nonendonucleolytic RISC. miR-214 is frequently overexpressed in ovarian cancer (Yang et al. 2008).
Literature References
PubMed ID Title Journal Year
18199536 MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

Kong, W, O'Donnell, JD, Kruk, PA, Zhao, JJ, He, L, Wenham, RM, Cheng, JQ, Nicosia, SV, Coppola, D, Wang, J, Yang, H

Cancer Res. 2008
Participants
Input
Output
Participates
as an event of
Authored
Salmena, L  (2016-08-11)
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-04)
Cite Us!