FUNDC1 is phosphorylated by CK2

Stable Identifier
R-HSA-8948039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FUNDC1-mediated mitophagy is inhibited by its phosphorylation at the Serine 13 positions in the LIR motif by CK2kinase under normoxia conditions. These phosphorylation events insure that FUNDC1 cannot bind LC3.

Literature References
PubMed ID Title Journal Year
24746696 A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy

Chen, G, Han, Z, Feng, D, Chen, Y, Chen, L, Wu, H, Huang, L, Zhou, C, Cai, X, Fu, C, Duan, L, Wang, X, Liu, L, Liu, X, Shen, Y, Zhu, Y, Chen, Q

Mol. Cell 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Casein kinase II [cytosol]
Physical Entity
Activity
Orthologous Events
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Created
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