ULK1 Translocates to the mitochondria

Stable Identifier
R-HSA-8948136
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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ULK1 Translocates to the mitochondria
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ULK1 is critical for the induction of autophagy, translocating to fragmented mitochondria upon mitophagy induction by either hypoxia or mitochondrial uncouplers. At mitochondria, ULK1 interacts with FUNDC1.
Literature References
PubMed ID Title Journal Year
24671035 ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Feng, D, Hu, Z, Tian, W, Zhang, L, Sui, S, Wu, W, Xue, P, Li, W, Zhang, X, Liu, L, Zhao, B, Zhou, C, Huang, L, Li, L, Zhu, Y, Chen, G, Zhang, X

EMBO Rep. 2014
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Orthologous Events
ULK1 Translocates to the mitochondria (Bos taurus)
ULK1 Translocates to the mitochondria (Caenorhabditis elegans)
ULK1 Translocates to the mitochondria (Canis familiaris)
ULK1 Translocates to the mitochondria (Dictyostelium discoideum)
ULK1 Translocates to the mitochondria (Drosophila melanogaster)
ULK1 Translocates to the mitochondria (Gallus gallus)
ULK1 Translocates to the mitochondria (Mus musculus)
ULK1 Translocates to the mitochondria (Rattus norvegicus)
ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)
ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)
ULK1 Translocates to the mitochondria (Sus scrofa)
ULK1 Translocates to the mitochondria (Xenopus tropicalis)
Authored
Gillespie, ME  (2016-11-02)
Reviewed
Feng, D  (2017-01-26)
Created
Gillespie, ME  (2016-11-11)
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