miR-19b microRNA binds PTEN mRNA

Stable Identifier
R-HSA-8948569
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-19b microRNA binds PTEN mRNA
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MicroRNA miR-19b, encoded by two genomic loci, MIR19B1 and MIR19B2, is homologous to miR-19a and also binds to the 3'UTR of PTEN mRNA (Polseno, Salmena, Zhang et al. 2010). miR-19b microRNA causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-19b microRNA also functions as a part of the nonendonucleolytic RISC.
Literature References
PubMed ID Title Journal Year
20577206 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Pandolfi, PP, Carver, B, Haveman, WJ, Poliseno, L, Zhang, J, Salmena, L

Nature 2010
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
miR-19b RISC:PTENP1 mRNA [cytosol] (Homo sapiens)
Active Unit
PTENP1 mRNA [cytosol]
Regulator
miR-19b RISC:CNOT6L mRNA [cytosol] (Homo sapiens)
Active Unit
CNOT6L mRNA [cytosol]
Authored
Orlic-Milacic, M  (2016-11-03)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-14)
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