Reactome | AKT phosphorylates MKRN1

AKT phosphorylates MKRN1

Stable Identifier

R-HSA-8948757

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - AKT phosphorylates targets in the cytosol (Homo sapiens)
      - AKT phosphorylates MKRN1 (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN stability and activity (Homo sapiens)
        
        AKT phosphorylates MKRN1 (Homo sapiens)

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AKT1 (and possibly AKT2 and AKT3), activated in response to EGF treatment, phosphorylates MKRN1, an E3 ubiquitin ligase, on serine residue S109. AKT-mediated phosphorylation results in stabilization of MKRN1, protecting it from ubiquitination and proteasome-mediated degradation (Lee et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26183061	PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis Lee, MS, Jeong, MH, Lee, HW, Han, HJ, Ko, A, Hewitt, SM, Kim, JH, Chun, KH, Chung, JY, Lee, C, Cho, H, Song, J	Nat Commun	2015