AKT phosphorylates MKRN1

Stable Identifier
R-HSA-8948757
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT1 (and possibly AKT2 and AKT3), activated in response to EGF treatment, phosphorylates MKRN1, an E3 ubiquitin ligase, on serine residue S109. AKT-mediated phosphorylation results in stabilization of MKRN1, protecting it from ubiquitination and proteasome-mediated degradation (Lee et al. 2015).

Literature References
PubMed ID Title Journal Year
26183061 PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Lee, MS, Jeong, MH, Lee, HW, Han, HJ, Ko, A, Hewitt, SM, Kim, JH, Chun, KH, Chung, JY, Lee, C, Cho, H, Song, J

Nat Commun 2015
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created