Reactome | p-S109-MKRN1 [cytosol]

p-S109-MKRN1 [cytosol]

Stable Identifier

R-HSA-8948758

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
26183061	PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis Hewitt, SM, Han, HJ, Lee, MS, Lee, C, Chung, JY, Kim, JH, Jeong, MH, Ko, A, Cho, H, Lee, HW, Song, J, Chun, KH	Nat Commun	2015

External Reference Information

External Reference

UniProt:Q9UHC7 MKRN1

Gene Names

MKRN1, RNF61

Chain

chain:1-482

Reference Genes

BioGPS Gene:23608 MKRN1

COSMIC (genes):MKRN1 MKRN1

CTD Gene:23608 MKRN1

dbSNP Gene:23608 MKRN1

ENSEMBL:ENSG00000133606 MKRN1

ENSEMBL_homo_sapiens_GENE:ENSG00000133606.11 MKRN1

HGNC:7112 MKRN1

KEGG Gene (Homo sapiens):23608 MKRN1

Monarch:23608 MKRN1

NCBI Gene:23608 MKRN1

OMIM:607754 MKRN1

UCSC:Q9UHC7 MKRN1

Reference Transcript

Other Identifiers

11718558_s_at

11728691_a_at

11745175_a_at

11751335_a_at

11751336_x_at

11754758_a_at

11757664_s_at

201285_PM_at

201285_at

209845_PM_at

209845_at

23608

3076176

3076177

3076179

3076180

3076181

3076183

3076185

3076186

3076187

3076188

3076189

3076191

3076192

3076194

3076199

3076200

3076213

3076214

3076215

3076216

3181086

3464558

37650_at

3974622

3983622

4028786

51678_at

8143387

A_23_P59798

A_24_P29703

A_24_P410627

GE58538

GE61600

GO:0000209

GO:0003723

GO:0003824

GO:0005515

GO:0005575

GO:0005829

GO:0016567

GO:0016740

GO:0036211

GO:0046872

GO:0061630

GO:0140096

HMNXSV003005987

HMNXSV003013462

ILMN_1671583

PH_hs_0000807

g6563239_3p_at

g7305272_3p_at

Participates

as an output of

AKT phosphorylates MKRN1 (Homo sapiens)

Other forms of this molecule

MKRN1 [cytosol]

Inferred To

phospho-MKRN1 [cytosol] (Bos taurus)

phospho-MKRN1 [cytosol] (Canis familiaris)

phospho-MKRN1 [cytosol] (Gallus gallus)

phospho-MKRN1 [cytosol] (Sus scrofa)

phospho-Mkrn1 [cytosol] (Drosophila melanogaster)

phospho-Mkrn1 [cytosol] (Mus musculus)

phospho-Mkrn1 [cytosol] (Rattus norvegicus)

phospho-lep-2 [cytosol] (Caenorhabditis elegans)

phospho-mkrn1 [cytosol] (Danio rerio)

phospho-mkrn1 [cytosol] (Xenopus tropicalis)

phospho-cps3 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S109-MKRN1 [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 109

Coordinate

109

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_011514300.1, NP_001138597.1, XP_011514299.1, NP_038474.2

OpenTargets

ENSG00000133606

GeneCards

Q9UHC7

HPA

ENSG00000133606-MKRN1

Ensembl

ENST00000255977, ENSP00000255977, ENST00000474576, ENSP00000417863, ENST00000443720, ENSG00000133606, ENSP00000416369

PRO

Q9UHC7

Pharos - Targets

Q9UHC7

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.602	8
UniProt:P41227 NAA10			0.556	5
UniProt:Q96DC9 OTUB2	2	OTUB2 [cytosol] (R-HSA-933410) OTUB2 [nucleoplasm] (R-HSA-6783260)	0.556	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.556	3
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	5
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	5
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.556	3
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.524	5

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