RNF146 polyubiquitinates PARylated PTEN

Stable Identifier
R-HSA-8948832
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The E3 ubiquitin ligase RNF146 possesses a PAR recognition domain (WWE) which binds to PARylated PTEN. RNF146 polyubiquitinates PARylated PTEN, with lysine residues K342, K344 and K349 as major ubiquitination sites. RNF146-mediated ubiquitination targets PTEN for proteasome-mediated degradation (Li et al. 2015).

Literature References
PubMed ID Title Journal Year
25547115 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

Li, N, Zhang, Y, Han, X, Liang, K, Wang, J, Feng, L, Wang, W, Songyang, Z, Lin, C, Yang, L, Yu, Y, Chen, J

Genes Dev. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RNF146 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created