RUNX3:CBFB binds the RORC gene promoter

Stable Identifier
R-HSA-8949276
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in mice, the complex of RUNX3 and CBFB binds the promoter of the RORC (RORgamma) gene, encoding nuclear retinoid-related orphan receptor-gamma. The RUNX binding site TGTGGT is conserved between mouse and human RORC promoters. Mouse Runx3 is expressed in innate lymphoid cell lineages ILC1 and ILC3, but not ILC2 (Ebihara et al. 2015).

Literature References
PubMed ID Title Journal Year
26414766 Runx3 specifies lineage commitment of innate lymphoid cells

Ebihara, T, Song, C, Ryu, SH, Plougastel-Douglas, B, Yang, L, Levanon, D, Groner, Y, Bern, MD, Stappenbeck, TS, Colonna, M, Egawa, T, Yokoyama, WM

Nat. Immunol. 2015
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