RORC gene expression is stimulated by RUNX3:CBFB

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Reaction [omitted]
Homo sapiens
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Based on mouse studies, binding of the RUNX3:CBFB heterodimer to the RUNX binding motif TGTGGT conserved between the mouse and human promoters of the RORC (RORgamma) gene, stimulates transcription of the RORC transcript variant 2 (RORC-2), also known as RORgT (RORgamma-t). In the ILC3 lineage of innate lymphoid cells in mice, expression of the Ahr transcription factor is positively indirectly regulated by Runx3, most likely through RORgT (Ebihara et al. 2015).

Literature References
PubMed ID Title Journal Year
26414766 Runx3 specifies lineage commitment of innate lymphoid cells

Ebihara, T, Song, C, Ryu, SH, Plougastel-Douglas, B, Yang, L, Levanon, D, Groner, Y, Bern, MD, Stappenbeck, TS, Colonna, M, Egawa, T, Yokoyama, WM

Nat. Immunol. 2015
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