RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter

Stable Identifier
R-HSA-8949335
Type
Reaction [binding]
Species
Homo sapiens
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RUNX3, presumably in complex with CBFB, binds the RUNX response element in the promoter of the ITGAL (CD11a) gene, encoding leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells (Puig-Kroger et al. 2003, Dominguez-Soto et al. 2005). RUNX3, as well as RUNX1, may also be involved in regulation of integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct binding of RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).

Literature References
PubMed ID Title Journal Year
16164020 RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters

Domínguez-Soto, A, Relloso, M, Vega, MA, Corbí, AL, Puig-Kröger, A

Immunobiology 2005
12855590 RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements

Puig-Kröger, A, Sanchez-Elsner, T, Ruiz, N, Andreu, EJ, Prosper, F, Jensen, UB, Gil, J, Erickson, P, Drabkin, H, Groner, Y, Corbí, AL

Blood 2003
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