ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB

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R-HSA-8949343
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Reaction [omitted]
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Homo sapiens
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Transcription of the ITGAL (CD11a) gene, is stimulated by binding of RUNX3, presumably in complex with CBFB, to the ITGAL promoter. ITGAL is a leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells. RUNX3, as well as RUNX1, positively regulate integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct regulation by RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).

Literature References
PubMed ID Title Journal Year
16164020 RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters

Domínguez-Soto, A, Relloso, M, Vega, MA, Corbí, AL, Puig-Kröger, A

Immunobiology 2005
12855590 RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements

Puig-Kröger, A, Sanchez-Elsner, T, Ruiz, N, Andreu, EJ, Prosper, F, Jensen, UB, Gil, J, Erickson, P, Drabkin, H, Groner, Y, Corbí, AL

Blood 2003
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