Reactome | IMMT (MIC60) [mitochondrial inner membrane]

IMMT (MIC60) [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949569

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

IMMT, MICOS complex subunit MIC60, MIC60_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16891 IMMT

Gene Names

IMMT, HMP, MIC60, MINOS2, PIG4, PIG52

Chain

transit peptide:1-33, chain:34-758

Reference Genes

BioGPS Gene:10989 IMMT

COSMIC (genes):IMMT IMMT

CTD Gene:10989 IMMT

dbSNP Gene:10989 IMMT

ENSEMBL:ENSG00000132305 IMMT

HGNC:6047 IMMT

Monarch:10989 IMMT

NCBI Gene:10989 IMMT

OMIM:600378 IMMT

UCSC:Q16891 IMMT

Reference Transcript

Other Identifiers

10989

11715552_a_at

11715553_s_at

11747392_x_at

11750128_s_at

11752417_a_at

11752789_s_at

16899846

200955_PM_at

200955_at

2562688

2562689

2562690

2562691

2562692

2562694

2562696

2562697

2562698

2562699

2562700

2562704

2562706

2562709

2562710

2562711

2562713

2562714

2562715

2562716

2562719

2562720

2562723

2562725

2562726

37659_at

3934637

8053533

85003_at

85005_g_at

A_23_P39844

A_24_P351304

A_33_P3314466

A_33_P3314468

A_33_P3314471

GE57777

GO:0001401

GO:0003723

GO:0005515

GO:0005739

GO:0005743

GO:0005758

GO:0007005

GO:0007007

GO:0016020

GO:0042407

GO:0043226

GO:0044284

GO:0051560

GO:0061024

GO:0061617

GO:0070050

GO:0140275

HMNXSV003006928

HMNXSV003014213

HMNXSV003018293

ILMN_1782579

L42572_at

PH_hs_0029552

TC02002052.hg

g5803114_3p_at

Participates

as a component of

MICOS [mitochondrial inner membrane] (Homo sapiens)

as an input of

Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)

Cross References

ENSEMBL

ENSP00000387262, ENST00000442664, ENST00000410111, ENSP00000396899, ENST00000449247, ENSP00000407788

OpenTargets

ENSG00000132305

HPA

ENSG00000132305-IMMT

PRO

Q16891

Pharos - Targets

Q16891

GlyGen

Q16891

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.643	3
UniProt:O75431 MTX2	1	MTX2 [mitochondrial outer membrane] (R-HSA-1252142)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	13
UniProt:Q8WYQ3 CHCHD10	2	4xHC-CHCHD10 [mitochondrial intermembrane space] (R-HSA-8874883) CHCHD10 [mitochondrial intermembrane space] (R-HSA-8874860)	0.602	4
UniProt:Q5VU43 MYOME			0.573	2
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.553	2
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.553	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.553	2
UniProt:C0HM83 SHMOS			0.544	5
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.527	2
UniProt:Q6UXV4 APOOL	3	APOOL (MIC27) [mitochondrial inner membrane] (R-HSA-8949612) APOOL [extracellular region] (R-HSA-8862979) APOOL [platelet alpha granule lumen] (R-HSA-8863003)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:P08559 PDHA1	1	PDHA1 [mitochondrial matrix] (R-HSA-69966)	0.499	4
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.463	4

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