Interleukin-12 dissociates from Interleukin-12 receptor

Stable Identifier
R-HSA-8950128
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Based on competition experiments with Iodine125-labeled Interleukin-12 (IL12) it was determined that IL12 can dissociate from the Interleukin-12 receptor. The association kinetics suggest mostly subsequent internalization of the IL12 (Chizzonite et al. 1992).

Literature References
PubMed ID Title Journal Year
9498755 Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex

Presky, DH, Minetti, LJ, Gillessen, S, Wilkinson, VL, Wu, CY, Gubler, U, Chizzonite, R, Gately, MK

J. Immunol. 1998
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