IL12B translocates from the cytosol to the extracellular region

Stable Identifier
R-HSA-8950179
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-12B traslocates to the extracellular space, Interleukin-12B monomer is traslocated to the extracellular space, IL12B is traslocated to the extracellular space
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Interleukin-12 subunit beta (IL12B, IL12p40) is secreted to the extracellular region.
Celecoxib and the 4-trifluoromethyl analogue of celecoxib (TFM-C) inhibit secretion of Interleukin-23, a dimer of Interleukin-23 subunit alpha (IL23A) and IL12B but do not affect the secretion of monomeric IL12B (McLaughlin et al. 2010).

This is a Black box event because the mechanism of IL12B secretion is unknown.

Literature References
PubMed ID Title Journal Year
20054003 Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP

McLaughlin, M, Alloza, I, Quoc, HP, Scott, CJ, Hirabayashi, Y, Vandenbroeck, K

J. Biol. Chem. 2010
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