Reactome | STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor

STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor

Stable Identifier

R-HSA-8950269

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor

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Interleukin-23 (IL23) induces Signal transducer and activator of transcription 3 (STAT3) and STAT4 phosphorylation. Non-receptor tyrosine-protein kinase TYK2 (TYK2) and Tyrosine-protein kinase JAK2 (JAK2) are believed to phosphorylate STAT3 and STAT4 (Parham et al. 2002). STAT3 is the most prominent STAT activated by IL23, contrasting with Interleukin-12 (IL12) which predominantly induces STAT4 activation (Parham et al. 2002). IL23 induces phosphorylation of STAT3 and STAT4 in NK-like T cells but neither in NK cells (van de Wetering et al. 2009). Phosphorylation results in STAT3:STAT4 heterodimer formation (Parham et al. 2002).
This is a black box event because the exact mechanism and order of STAT3/STAT4 binding is unknown.

Literature References

PubMed ID	Title	Journal	Year
25516297	IL12Rβ1: the cytokine receptor that we used to know Robinson, RT	Cytokine	2015
12023369	A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R Vaisberg, E, Wagner, J, Gorman, D, Singh, KP, Travis, M, Parham, C, To, W, Zhang, R, Kastelein, RA, Zurawski, S, Cheung, J, McClanahan, T, O'Farrell, AM, Timans, J, Pflanz, S, Rennick, DM, Vega, F, Moore, KW, de Waal Malefyt, R, Hannum, C, Chirica, M	J Immunol	2002