IL12A:IL12B translocates from late endosome lumen to extracellular region

Stable Identifier
R-HSA-8950347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-12 translocates to the extracellular space, IL12A:IL12B complex is translocated to the extracellular space, Interleukin-12A:Interleukin12-B complex is translocated to the extracellular space
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Vesicle-associated membrane protein 7 (VAMP7) plays a dual role in Interleukin-12 heterodimeric protein secretion. In individual Dendritic cells, its basic function is as a positive regulator, regulating the optimal exocytosis of biologically active Interleukin-12 heterodimer produced by inflammatory stimuli. The second essential role of VAMP7 is as a negative regulator, controling non-redundantly synaptic secretion of the cytokine during interaction with a cognate T cell, i.e., at the immune synapse. Multivesicular bodies are regulated by VAMP7 and consequently Interleukin-12 heterodimer secretion is regulated by this VAMP7 (Chiaruttini et al. 2016).

Literature References
PubMed ID Title Journal Year
26972013 The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells

Chiaruttini, G, Piperno, GM, Jouve, M, De Nardi, F, Larghi, P, Peden, AA, Baj, G, Müller, S, Valitutti, S, Galli, T, Benvenuti, F

Cell Rep 2016
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