IL23R in IL23:IL23 receptor complex is phosphorylated

Stable Identifier
R-HSA-8950364
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inferred from mouse:
Interleukin-23 receptor subunit (Il23r) can be phosphoryated at various intracellular Tyrosin residues. Tyr-542 and Tyr-626 aminoacid residues in murine Il23r are responsible for SH2 domain dependent Signal transducer and activator of transcription 3 (Stat3) activation (Floss et al. 2013). Moreover Western blot data demostrated Interleukin-23 dependent trysoine phosphorylation of Stat3 in cotransfected parental cell lines(2C4, 2fTGH) and Tyrosine-protein kinase JAK1(Jak1)-deficient cells (U4C) (Floss et al.2016).
As the process of phosphorylation is not clear this reaction is represented here as a black box event.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created