CANX binds EBI3

Stable Identifier
R-HSA-8950387
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-27 subunit beta binds Calnexin
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Calnexin (CANX or p95 calnexin) binds Interleukin-27 subunit beta (EBI3, IL27B). In human cell lines (BL30, BL41, Louckes, BJAB, P3HR1) most newly synthesized EBI3 is retained in the endoplasmic reticulum (ER) in an endoglycosidase H-sensitive form (Devergne et al. 1996, 1997), bound to CANX and a 60-kDa protein and transiently with a p75-kDa protein, both ignored here). EBI3 can be released by itself but the association with CANX prevents this, the complex is retained in the ER. The co-expression of other interleukin subunits enables the release of EBI3 in a complex with Interleukin-27 subunit alpha (IL27) (Devergne et al. 1996).

Literature References
PubMed ID Title Journal Year
8483502 A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

Milburn, MV, Hassell, AM, Lambert, MH, Jordan, SR, Proudfoot, AE, Graber, P, Wells, TN

Nature 1993
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Devergne, O, Birkenbach, M, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
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