Reactome | CANX binds EBI3

CANX binds EBI3

Stable Identifier

R-HSA-8950387

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Interleukin-27 subunit beta binds Calnexin

ReviewStatus

5/5

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Calnexin (CANX or p95 calnexin) binds Interleukin-27 subunit beta (EBI3, IL27B). In human cell lines (BL30, BL41, Louckes, BJAB, P3HR1) most newly synthesized EBI3 is retained in the endoplasmic reticulum (ER) in an endoglycosidase H-sensitive form (Devergne et al. 1996, 1997), bound to CANX and a 60-kDa protein and transiently with a p75-kDa protein, both ignored here). EBI3 can be released by itself but the association with CANX prevents this, the complex is retained in the ER. The co-expression of other interleukin subunits enables the release of EBI3 in a complex with Interleukin-27 subunit alpha (IL27) (Devergne et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
9342359	Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin Birkenbach, M, Devergne, O, Kieff, E	Proc. Natl. Acad. Sci. U.S.A.	1997
8483502	A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5 Hassell, AM, Milburn, MV, Proudfoot, AE, Wells, TN, Graber, P, Jordan, SR, Lambert, MH	Nature	1993