IL12B:IL12B translocates from ER lumen to the extracellular region

Stable Identifier
R-HSA-8950410
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-12 subunit beta homodimer traslocates to the extracellular region.
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Interleukin-12 subunit beta (IL12B, IL-12p40) can form oligomers with other interleukin subunits or be secreted as a monomer to the extracellular region (Ling et al. 1995).
Production of human IL12B homodimers has only been detected in cells with IL-12p40 expression constructs (Ling et al 1995, Alloza & Vandenbroeck 2015), not in natural conditions (Carra et al 2000).

Literature References
PubMed ID Title Journal Year
15720785 The metallopeptide antibiotic bacitracin inhibits interleukin-12 alphabeta and beta2 secretion

Alloza, I, Vandenbroeck, K

J. Pharm. Pharmacol. 2005
7527811 Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

Ling, P, Gately, MK, Gubler, U, Stern, AS, Lin, P, Hollfelder, K, Su, C, Pan, YC, Hakimi, J

J. Immunol. 1995
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