JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated

Stable Identifier
R-HSA-8950423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
JAK2 and TYK2 activation after IL12:IL12R interaction
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Interleukin-12 phosphorylates and thereby activates Tyrosine-protein kinase JAK2 (JAK2) and non-receptor tyrosine-protein kinase TYK2 (TYK2) (Bacon et al.1995, Kanda & Watanabe 2008).

Literature References
PubMed ID Title Journal Year
7638186 Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

Bacon, CM, Petricoin, EF, Ortaldo, JR, Rees, RC, Larner, AC, Johnston, JA, O'Shea, JJ

Proc. Natl. Acad. Sci. U.S.A. 1995
18389480 IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes

Kanda, N, Watanabe, S

Eur. J. Immunol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created