Reactome | JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated

JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated

Stable Identifier

R-HSA-8950423

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

JAK2 and TYK2 activation after IL12:IL12R interaction

ReviewStatus

5/5

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JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated

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Interleukin-12 phosphorylates and thereby activates Tyrosine-protein kinase JAK2 (JAK2) and non-receptor tyrosine-protein kinase TYK2 (TYK2) (Bacon et al.1995, Kanda & Watanabe 2008).

Literature References

PubMed ID	Title	Journal	Year
18389480	IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes Kanda, N, Watanabe, S	Eur. J. Immunol.	2008
7638186	Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes Ortaldo, JR, Johnston, JA, Petricoin, EF, Rees, RC, Bacon, CM, O'Shea, JJ, Larner, AC	Proc. Natl. Acad. Sci. U.S.A.	1995