Reactome | p-Y-IL6ST [plasma membrane]

p-Y-IL6ST [plasma membrane]

Stable Identifier

R-HSA-8950439

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Literature References

PubMed ID	Title	Journal	Year
14764690	WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 Kastelein, RA, Phillips, JH, Vaisberg, E, Rosales, R, Hibbert, L, Pflanz, S, Bazan, JF, Mattson, J, de Waal Malefyt, R, McClanahan, TK	J Immunol	2004

External Reference Information

External Reference

UniProt:P40189 IL6ST

Gene Names

IL6ST

Chain

signal peptide:1-22, chain:23-918

Reference Genes

BioGPS Gene:3572 IL6ST

COSMIC (genes):IL6ST IL6ST

CTD Gene:3572 IL6ST

dbSNP Gene:3572 IL6ST

ENSEMBL:ENSG00000134352.20 IL6ST

HGNC:6021 IL6ST

KEGG Gene (Homo sapiens):3572 IL6ST

Monarch:3572 IL6ST

NCBI Gene:3572 IL6ST

OMIM:600694 IL6ST

UCSC:P40189 IL6ST

Reference Transcript

Other Identifiers

0002230292

0002510008

11730757_a_at

11730758_a_at

11753579_a_at

11753878_s_at

11753879_x_at

11753886_a_at

11759037_s_at

11759038_at

16996298

204863_PM_s_at

204863_s_at

204864_PM_s_at

204864_s_at

211000_PM_s_at

211000_s_at

212195_PM_at

212195_at

212196_3p_at

212196_PM_at

212196_at

2857410

2857411

2857412

2857413

2857414

2857415

2857417

2857418

2857419

2857420

2857421

2857422

2857423

2857429

2857430

2857436

2857437

2857438

2857439

2857440

2857441

2857443

2857444

2857447

2857448

2857449

2857450

2857452

2857453

2857455

2857457

2857462

2857463

2857464

3572

35842_at

3711799

3711801

3711805

3711824

37621_at

64136_at

8112139

A_23_P502470

A_32_P223777

A_33_P3233834

A_33_P3233841

A_33_P3233843

A_33_P3287338

GE56146

GE57980

GO:0002376

GO:0002675

GO:0002821

GO:0003012

GO:0004896

GO:0004897

GO:0004915

GO:0004921

GO:0004923

GO:0004924

GO:0005127

GO:0005138

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005896

GO:0005900

GO:0005975

GO:0005977

GO:0006091

GO:0006954

GO:0007155

GO:0007165

GO:0008284

GO:0008593

GO:0009897

GO:0010575

GO:0010613

GO:0012501

GO:0016020

GO:0016021

GO:0019221

GO:0019838

GO:0019955

GO:0019970

GO:0019981

GO:0023052

GO:0030154

GO:0030425

GO:0032991

GO:0034097

GO:0036211

GO:0038154

GO:0038165

GO:0042060

GO:0042102

GO:0042531

GO:0042802

GO:0043025

GO:0043066

GO:0043226

GO:0043235

GO:0043524

GO:0044297

GO:0045121

GO:0045509

GO:0045669

GO:0045747

GO:0048711

GO:0048856

GO:0048861

GO:0060089

GO:0060576

GO:0070062

GO:0070102

GO:0070104

GO:0070106

GO:0070110

GO:0070120

GO:0097110

GO:1901731

HMNXSV003050368

HMNXSV003057074

Hs.71968.0.A1_3p_at

Hs.71968.0.A1_3p_s_at

Hs.71968.0.A1_3p_x_at

Hs.71968.0.A2_3p_at

Hs.82065.0.A1_3p_a_at

ILMN_1746604

ILMN_1797861

ILMN_1849013

M57230_at

PH_hs_0027667

TC05001366.hg

TC05003005.hg

g4504674_3p_a_at

Participates

as a component of

p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

IL6ST [plasma membrane]

Inferred To

phospho-p-Y-IL6ST [plasma membrane] (Canis familiaris)

phospho-IL6ST [plasma membrane] (Bos taurus)

phospho-IL6ST [plasma membrane] (Sus scrofa)

phospho-Il6st [plasma membrane] (Mus musculus)

phospho-Il6st [plasma membrane] (Rattus norvegicus)

phospho-gp130 [plasma membrane] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001177910.1, NP_786943.1, NP_002175.2

Guide to Pharmacology - Targets

2317

OpenTargets

ENSG00000134352

GeneCards

P40189

HPA

ENSG00000134352-IL6ST

Ensembl

ENSP00000370694, ENSP00000435399, ENSP00000462158, ENST00000502326, ENSG00000134352, ENSP00000370698, ENST00000381294, ENST00000381298, ENST00000522633

PRO

P40189

Pharos - Targets

P40189

PDB

1I1R, 1P9M, 3L5H, 3L5J, 1BQU, 3L5I, 1PVH, 1BJ8

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.691	10
UniProt:Q96EQ0 SGTB			0.666	4
UniProt:P42227 Stat3	13	phospho-Stat3 [nucleoplasm] (R-MMU-1112554) phospho-Stat3 [cytosol] (R-MMU-914048) Stat3 [cytosol] (R-MMU-539044) Stat3 [cytosol] (R-MMU-914084) p-Y705-Stat3 [cytosol] (R-MMU-914034) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) phospho-Stat3 [cytosol] (R-MMU-539048) phospho-Stat3 [cytosol] (R-MMU-8983130) phospho-Stat3 [nucleoplasm] (R-MMU-9027589) phospho-Stat3 [nucleoplasm] (R-MMU-9701429) phospho-Stat3 [nucleoplasm] (R-MMU-9701435) phospho-Stat3 [cytosol] (R-MMU-8982823) phospho-Stat3 [nucleoplasm] (R-MMU-8983188)	0.656	4
UniProt:P15018 LIF	1	LIF [extracellular region] (R-HSA-5696436)	0.623	2
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.601	7
UniProt:P13725 OSM	1	OSM [extracellular region] (R-HSA-5696440)	0.59	2
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:P43364 MAGAB			0.556	3
UniProt:Q9NZI2-2 Q9NZI22-1			0.556	3
UniProt:P05231 IL6	3	p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) IL6 [extracellular region] (R-HSA-447100)	0.553	2
UniProt:Q2HRC7 VIL6			0.544	2

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