p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus

Stable Identifier
R-HSA-8950724
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin-23 receptor signaling leads to Signal transducer and activator of transcription 3/Signal transducer and activator of transcription 4 (STAT3:STAT4) heterodimer activation in addition to the activation of STAT3 homodimers. Although Interleukin 23 activates the same spectrum of JAK/STAT molecules as interleukin 12, Interleukin-23 activates STAT4 to a lesser extent (Oppmann et al. 2000, Parham et al. 2012). The STAT3:STAT4 heterodimer translocates to the nucleus.
This reaction is presented as a black box event because the exact mechanism of translocation to the nucleus is unknown.

Literature References
PubMed ID Title Journal Year
26109132 Genetic susceptibility to invasive Salmonella disease

Gilchrist, JJ, MacLennan, CA, Hill, AV

Nat. Rev. Immunol. 2015
Participants
Participant Of
Orthologous Events
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Reviewed
Created