Reactome | CRLF1:IL27 translocates to the extracellular region

CRLF1:IL27 translocates to the extracellular region

Stable Identifier

R-HSA-8950731

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region

Synonyms

Cytokine receptor like factor-1:Interleukin-27 subunit alpha complex translocates to the extracelular region.

ReviewStatus

5/5

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CRLF1:IL27 translocates to the extracellular region

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Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytokine like factor 1 (CRLF1) form a secreted complex. Secretion of IL27 was observed in HEK 293 cells transfected with IL27 cDNA in the absence of CRLF1. This may indicate that formation of a complex is not strictly required for IL27 secretion in these cells. Alternatively it could reflect the formation of a complex between IL27 and endogenous CRLF1, which is expressed in HEK 293 cells. The IL27:CRLF1 complex is biologically active (Crabé et al. 2009).

This reaction is a black box event because the mechanism of translocation is unknown.

Literature References

PubMed ID	Title	Journal	Year
19933857	The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling Ferlin, W, Mavoungou-Bigouagou, U, Guilhot, F, Tormo, AJ, Crabé, S, Lissilaa, R, Duluc, D, Lefouili, F, Jeannin, P, Gauchat, JF, Elson, G, Cognet, I, Guay-Giroux, A	J. Immunol.	2009