CANX dissociates from IL12A:EBI3

Stable Identifier
R-HSA-8950740
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin-12 subunit alpha (IL12A, IL12p35) binds Interleukin-27 subunit beta (EBI3) forming the Interleukin-35 heterodimeric complex (IL12A:EBI3)(Devergne et al.). When expressed alone, human EBI3 is associated with the endoplasmic reticulum (ER) resident molecular chaperone calnexin (CANX) and is retained in the ER (Devergne et al. 1997). Co-expression of IL27 and EBI3 enables formation of IL27:EBI3, allowing secretion (Pflanz et al. 2002).

This is a Black Box event because there is not reported wich reaction occurs first: the association of IL12A to EBI3:CANX and later the Interleukin-35 heterodimeric protein formation.

Literature References
PubMed ID Title Journal Year
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Devergne, O, Birkenbach, M, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Pflanz, S, Timans, JC, Cheung, J, Rosales, R, Kanzler, H, Gilbert, J, Hibbert, L, Churakova, T, Travis, M, Vaisberg, E, Blumenschein, WM, Mattson, JD, Wagner, JL, To, W, Zurawski, S, McClanahan, TK, Gorman, DM, Bazan, JF, de Waal Malefyt, R, Rennick, D, Kastelein, RA

Immunity 2002
Participants
Participant Of
Authored
Reviewed
Created