RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

Stable Identifier
R-HSA-8951428
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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General
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RUNX3 forms a ternary complex with beta-catenin (CTNNB1) and its binding partner TCF7L2 (TCF4). In addition to TCF7L2, RUNX3 is also able to interact with LEF1, TCF7L1 (TCF3) and TCF7 (also known as TCF1). The interaction involves the Runt domain of RUNX3 and the HMG box of TCF7L2 (Ito et al. 2008).

Literature References
PubMed ID Title Journal Year
18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

Ito, K, Lim, AC, Salto-Tellez, M, Motoda, L, Osato, M, Chuang, LS, Lee, CW, Voon, DC, Koo, JK, Wang, H, Fukamachi, H, Ito, Y

Cancer Cell 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created