RUNX3 regulates WNT signaling

Stable Identifier
R-HSA-8951430
Type
Pathway
Species
Homo sapiens
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RUNX3 binds to complexes of beta-catenin (CTNNB1) and TCF/LEF family members. Binding of RUNX3 to CTNNB1:TCF/LEF complexes prevents their loading onto cyclin D1 (CCND1) and MYC gene promoters and interferes with WNT signaling-mediated activation of CCND1 and MYC1 transcription. RUNX3 therefore inhibits WNT-induced cellular proliferation (Ito et al. 2008).

Literature References
PubMed ID Title Journal Year
18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

Ito, K, Lim, AC, Salto-Tellez, M, Motoda, L, Osato, M, Chuang, LS, Lee, CW, Voon, DC, Koo, JK, Wang, H, Fukamachi, H, Ito, Y

Cancer Cell 2008
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
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Created