RUNX3 binds to complexes of beta-catenin (CTNNB1) and TCF/LEF family members. Binding of RUNX3 to CTNNB1:TCF/LEF complexes prevents their loading onto cyclin D1 (CCND1) and MYC gene promoters and interferes with WNT signaling-mediated activation of CCND1 and MYC1 transcription. RUNX3 therefore inhibits WNT-induced cellular proliferation (Ito et al. 2008).
Ito, K, Lim, AC, Salto-Tellez, M, Motoda, L, Osato, M, Chuang, LS, Lee, CW, Voon, DC, Koo, JK, Wang, H, Fukamachi, H, Ito, Y
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