Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1

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R-HSA-8951443
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Reaction [omitted]
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Homo sapiens
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Binding of the complex of beta-catenin (CTNNB1) and TCF7L2 (TCF4) or LEF1 transcription factors to TCF/LEF binding sites in the promoter of the cyclin D1 (CCND1) gene stimulates CCND1 transcription (Tetsu and McCormick 1999, Shtutman et al. 1999).

Literature References
PubMed ID Title Journal Year
10201372 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O, McCormick, F

Nature 1999
10318916 The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

Shtutman, M, Zhurinsky, J, Simcha, I, Albanese, C, D'Amico, M, Pestell, R, Ben-Ze'ev, A

Proc. Natl. Acad. Sci. U.S.A. 1999
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