CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85

Stable Identifier
R-HSA-8951490
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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High concentrations of active CDC42 (bound to GTP) and Beta-Pix may promote the binding of Beta-Pix to CBL, pushing out the usually preferred binding partner CIN85 (SH3KBP1) from the CBL complex. This competitive mechanism could block the CIN85-imposed clustering phenomenon on CBL that is required for tighter binding (Schmidt et al. 2006).
Literature References
PubMed ID Title Journal Year
16407834 Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix

Schmidt, MH, Szymkiewicz, I, Husnjak, K, Dikic, I, Haglund, K

Oncogene 2006
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