CALR, TAP, TAPBP dissociate from SEC22B:STX4

Stable Identifier
R-HSA-8951595
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The interaction between the two compartments involves either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).

Literature References
PubMed ID Title Journal Year
22153078 Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells

Cebrian, I, Visentin, G, Blanchard, N, Jouve, M, Bobard, A, Moita, C, Enninga, J, Moita, LF, Amigorena, S, Savina, A

Cell 2011
Participants
Participant Of
Event Information
Orthologous Events
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Created