Transfer of NEDD8 to AcM-UBE2M

Stable Identifier
R-HSA-8951661
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

UBA3:NAE1 transfers NEDD8 to the catalytic cysteine residue of UBE2M. Because two of the three E1-E2 interaction interfaces are created by conformational states present in the doubly-NEDDylated NAE1, transfer of NEDD8 to UBE2M is thought to weaken the interaction between UBA3:NAE1 and UBE2M, contributing to UBE2M release (Walden et al, 2003; Huang et al, 2004; Hunag et al, 2005; Huang et al, 2007).

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NEDD8 transferase activity of AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol]
Physical Entity
Activity
Orthologous Events