RUNX3 regulates YAP1-mediated transcription

Stable Identifier
R-HSA-8951671
Type
Pathway
Species
Homo sapiens
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Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).

Literature References
PubMed ID Title Journal Year
18579750 TEAD mediates YAP-dependent gene induction and growth control

Zhao, B, Ye, X, Yu, J, Li, L, Li, W, Li, S, Yu, J, Lin, JD, Wang, CY, Chinnaiyan, AM, Lai, ZC, Guan, KL

Genes Dev. 2008
10228168 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

Yagi, R, Chen, LF, Shigesada, K, Murakami, Y, Ito, Y

EMBO J. 1999
26364597 RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer

Qiao, Y, Lin, SJ, Chen, Y, Voon, DC, Zhu, F, Chuang, LS, Wang, T, Tan, P, Lee, SC, Yeoh, KG, Sudol, M, Ito, Y

Oncogene 2016
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