cAMP binds PKA tetramer

Stable Identifier
R-HSA-8951727
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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cAMP binds PKA tetramer
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Protein kinase A (PKA) regulatory subunit isoforms differ in their tissue specificity and functional characteristics. The isoform activated in response to glucagon signaling is not known.

PKA kinase is a tetramer of two regulatory and two catalytic subunits. The regulatory subunits block the activity of the catalytic subunits.

cAMP binds the regulatory subunits, which leads to dissociation of the tetramer into two active dimers made up of a regulatory and a catalytic subunit.
Literature References
PubMed ID Title Journal Year
16407073 Dynamic binding of PKA regulatory subunit RI alpha

Kim, C, Taylor, SS, McCammon, JA, Gullingsrud, J

Structure 2006
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Orthologous Events
cAMP binds PKA tetramer (Bos taurus)
cAMP binds PKA tetramer (Caenorhabditis elegans)
cAMP binds PKA tetramer (Canis familiaris)
cAMP binds PKA tetramer (Danio rerio)
cAMP binds PKA tetramer (Drosophila melanogaster)
cAMP binds PKA tetramer (Gallus gallus)
cAMP binds PKA tetramer (Mus musculus)
cAMP binds PKA tetramer (Rattus norvegicus)
cAMP binds PKA tetramer (Saccharomyces cerevisiae)
cAMP binds PKA tetramer (Schizosaccharomyces pombe)
cAMP binds PKA tetramer (Sus scrofa)
cAMP binds PKA tetramer (Xenopus tropicalis)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Castagnoli, L  (2008-11-06)
Created
Jupe, S  (2016-12-09)
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