RUNX3 binds EP300

Stable Identifier
R-HSA-8951951
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The histone acetyltransferase EP300 (p300) forms a complex with RUNX3, presumably bound to CBFB (Jin et al. 2004, Lee et al. 2013). EP300 can also form a complex with other RUNX family members, RUNX1 and RUNX2 (Jin et al. 2004).

Literature References
PubMed ID Title Journal Year
15138260 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

Jin, YH, Jeon, EJ, Li, QL, Lee, YH, Choi, JK, Kim, WJ, Lee, KY, Bae, SC

J. Biol. Chem. 2004
24229708 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma

Lee, YS, Lee, JW, Jang, JW, Chi, XZ, Kim, JH, Li, YH, Kim, MK, Kim, DM, Choi, BS, Kim, EG, Chung, JH, Lee, OJ, Lee, YM, Suh, JW, Chuang, LS, Ito, Y, Bae, SC

Cancer Cell 2013
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