HDAC4 deacetylates RUNX3

Stable Identifier
R-HSA-8952069
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Histone deacetylase HDAC4, recruited to RUNX3 by CCND1 (cyclin D1), deacetylates RUNX3, leading to BRD2 dissociation (Lee et al. 2013).

Literature References
PubMed ID Title Journal Year
24229708 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma

Lee, YS, Lee, JW, Jang, JW, Chi, XZ, Kim, JH, Li, YH, Kim, MK, Kim, DM, Choi, BS, Kim, EG, Chung, JH, Lee, OJ, Lee, YM, Suh, JW, Chuang, LS, Ito, Y, Bae, SC

Cancer Cell 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein deacetylase activity of Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created