RUNX proteins bind the p14-ARF promoter at the CDKN2A locus

Stable Identifier
R-HSA-8952081
Type
Reaction [binding]
Species
Homo sapiens
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The CDKN2A gene promoter that regulates transcription of p14-ARF contains Runx response elements that are known to be recognized by the RUNX1:CBFB complex (Linggi et al. 2002). Based on sequence similarity between RUNX1 and RUNX3 and the fact that the complex of acetylated RUNX3 and BRD2 positively regulate p14-ARF transcription, it is possible that RUNX3 can also bind to the Runx response elements at the p14-ARF promoter (Lee et al. 2013).

Literature References
PubMed ID Title Journal Year
12091906 The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia

Linggi, B, Müller-Tidow, C, van de Locht, L, Hu, M, Nip, J, Serve, H, Berdel, WE, van der Reijden, B, Quelle, DE, Rowley, JD, Cleveland, J, Jansen, JH, Pandolfi, PP, Hiebert, SW

Nat. Med. 2002
24229708 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma

Lee, YS, Lee, JW, Jang, JW, Chi, XZ, Kim, JH, Li, YH, Kim, MK, Kim, DM, Choi, BS, Kim, EG, Chung, JH, Lee, OJ, Lee, YM, Suh, JW, Chuang, LS, Ito, Y, Bae, SC

Cancer Cell 2013
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