Reactome | p14-ARF transcription is stimulated by RUNX proteins

p14-ARF transcription is stimulated by RUNX proteins

Stable Identifier

R-HSA-8952101

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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p14-ARF transcription is stimulated by RUNX proteins

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Binding of the RUNX1:CBFB complex to the p14-ARF promoter at the CDKN2A locus promotes p14-ARF transcription (Linggi et al. 2002). The complex of acetylated RUNX3 and BRD2 positively regulates p14-ARF transcription, leading to activation of TP53 (p53) in response to oncogenic KRAS signaling. It is possible that RUNX3 directly binds to Runx response elements in the p14-ARF promoter that are recognized by RUNX1, although the direct association of RUNX3 with the CDKN2A gene has not been examined (Lee et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
12091906	The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia Linggi, B, Müller-Tidow, C, van de Locht, L, Hu, M, Nip, J, Serve, H, Berdel, WE, van der Reijden, B, Quelle, DE, Rowley, JD, Cleveland, J, Jansen, JH, Pandolfi, PP, Hiebert, SW	Nat. Med.	2002
24229708	Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma Lee, YS, Lee, JW, Jang, JW, Chi, XZ, Kim, JH, Li, YH, Kim, MK, Kim, DM, Choi, BS, Kim, EG, Chung, JH, Lee, OJ, Lee, YM, Suh, JW, Chuang, LS, Ito, Y, Bae, SC	Cancer Cell	2013