RUNX3 can bind to TP53 (p53). The interaction involves the C-termini of both RUNX3 and TP53. RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21). RUNX3 may also interact with phosphorylated ATM kinase in response to DNA damage and facilitate ATM-mediated phosphorylation and stabilization of TP53 (Yamada et al. 2010).
Yamada, C, Ozaki, T, Ando, K, Suenaga, Y, Inoue, K, Ito, Y, Okoshi, R, Kageyama, H, Kimura, H, Miyazaki, M, Nakagawara, A
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