RUNX3 regulates BCL2L11 (BIM) transcription

Stable Identifier
R-HSA-8952158
Type
Pathway
Species
Homo sapiens
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In response to TGF-beta signaling, RUNX3, in cooperation with activated SMADs and FOXO3A, induces transcription of the pro-apoptotic gene BCL2L11 (BIM) (Wildey et al. 2003, Yano et al. 2006, Yamamura et al. 2006).

Literature References
PubMed ID Title Journal Year
16738314 The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

Yano, T, Ito, K, Fukamachi, H, Chi, XZ, Wee, HJ, Inoue, K, Ida, H, Bouillet, P, Strasser, A, Bae, SC, Ito, Y

Mol. Cell. Biol. 2006
12637528 Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes

Wildey, GM, Patil, S, Howe, PH

J. Biol. Chem. 2003
16373335 RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells

Yamamura, Y, Lee, WL, Inoue, K, Ida, H, Ito, Y

J. Biol. Chem. 2006
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