RUNX3 binds the BCL2L11 (BIM) gene

Stable Identifier
R-HSA-8952226
Type
Reaction [binding]
Species
Homo sapiens
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In response to TGF-beta treatment, RUNX3 binds to Runx response elements in the promoter of the BCL2L11 (BIM) gene. The BCL2L11 promoter contains three Runx response elements, one SMAD-binding site, and a binding site for FOXO3 (FOXO3A). The SMAD binding site is needed for RUNX3-mediated upregulation of BCL2L11 transcription and was shown to bind SMAD3 (Wildey et al. 2003). FOXO3 can bind to the BCL2L11 promoter synergistically with RUNX3 and contribute to BCL2L11 stimulation (Yamamura et al. 2006).

Literature References
PubMed ID Title Journal Year
16738314 The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

Yano, T, Ito, K, Fukamachi, H, Chi, XZ, Wee, HJ, Inoue, K, Ida, H, Bouillet, P, Strasser, A, Bae, SC, Ito, Y

Mol. Cell. Biol. 2006
12637528 Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes

Wildey, GM, Patil, S, Howe, PH

J. Biol. Chem. 2003
16373335 RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells

Yamamura, Y, Lee, WL, Inoue, K, Ida, H, Ito, Y

J. Biol. Chem. 2006
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