Reactome | FAM20C [endoplasmic reticulum lumen]

FAM20C [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8952276

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

fullName evidence="13"Extracellular serine/threonine protein kinase FAM20C ecNumber evidence="7 8 9"2.7.11.1/ecNumber, FA20C_HUMAN

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External Reference Information

External Reference

UniProt:Q8IXL6 FAM20C

Gene Names

FAM20C, DMP4

Chain

signal peptide:1-22, propeptide:23-92, chain:93-584

Reference Genes

BioGPS Gene:56975 FAM20C

COSMIC (genes):FAM20C FAM20C

CTD Gene:56975 FAM20C

dbSNP Gene:56975 FAM20C

ENSEMBL:ENSG00000177706 FAM20C

ENSEMBL:ENSG00000288499 FAM20C

HGNC:22140 FAM20C

KEGG Gene (Homo sapiens):56975 FAM20C

Monarch:56975 FAM20C

NCBI Gene:56975 FAM20C

OMIM:611061 FAM20C

UCSC:Q8IXL6 FAM20C

Reference Transcript

RefSeq:NM_020223.3 FAM20C

Other Identifiers

0003060731

11731678_s_at

11731679_x_at

17042681

226722_at

2986724

2986728

2986729

2986730

2986731

2986732

2986733

56975

72964_at

8130993

90257_at

A_23_P250122

GE86504

GO:0000166

GO:0001501

GO:0002376

GO:0003674

GO:0004674

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0006464

GO:0006468

GO:0007165

GO:0008150

GO:0016301

GO:0016310

GO:0016740

GO:0016773

GO:0021700

GO:0030145

GO:0030154

GO:0030501

GO:0031214

GO:0036179

GO:0040036

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0045669

GO:0046034

GO:0046872

GO:0048646

GO:0048856

GO:0051174

GO:0070062

GO:0070166

GO:0071895

GO:0097187

Hs.134742.0.S1_3p_at

ILMN_1683165

ILMN_1703009

ILMN_1705982

ILMN_1712684

PH_hs_0027843

TC07000004.hg

Participant Of

hasComponent

Inferred To

fam20cb [endoplasmic reticulum lumen] (Danio rerio)

FAM20C [endoplasmic reticulum lumen] (Bos taurus)

FAM20C [endoplasmic reticulum lumen] (Canis familiaris)

FAM20C [endoplasmic reticulum lumen] (Drosophila melanogaster)

FAM20C [endoplasmic reticulum lumen] (Gallus gallus)

FAM20C [endoplasmic reticulum lumen] (Sus scrofa)

Homologues of FAM20C [endoplasmic reticulum lumen] (Danio rerio)

fam20c [endoplasmic reticulum lumen] (Xenopus tropicalis)

famk-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Fam20c [endoplasmic reticulum lumen] (Mus musculus)

Fam20c [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_064608.2

OpenTargets

ENSG00000177706

IntEnz

2.7.11.1

GeneCards

Q8IXL6

HPA

ENSG00000177706-FAM20C

Ensembl

ENST00000313766, ENSG00000177706, ENSP00000322323

PRO

Q8IXL6

Orphanet

16801

HMDB Protein

HMDBP07650

PDB

5YH3

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10451 SPP1	5	SPP1 [endoplasmic reticulum lumen] (R-HSA-8956713) SPP1 [extracellular region] (R-HSA-215967) p-SPP1 [endoplasmic reticulum lumen] (R-HSA-8956883) SPP1(17-?) [extracellular region] (R-HSA-4093351) SPP1(?-314) [extracellular region] (R-HSA-4093349)	0.636	3
UniProt:P02671 FGA	8	FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905) FGA(20-866) [extracellular region] (R-HSA-140841) FGA(20-35) [extracellular region] (R-HSA-140867) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) FGA [plasma membrane] (R-HSA-140916) FGA [extracellular region] (R-HSA-140583)	0.623	2

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