MDM2 binds RUNX3

Stable Identifier
R-HSA-8952371
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MDM2 and RUNX3 form a complex in the nucleus. Association of RUNX3 with CBFB does not interfere with binding of MDM2 to RUNX3. The interaction involves the acidic domain of MDM2 and the Runt domain of RUNX3 (Chi et al. 2009).

Literature References
PubMed ID Title Journal Year
19808967 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Chi, XZ, Kim, J, Lee, YH, Lee, JW, Lee, KS, Wee, H, Kim, WJ, Park, WY, Oh, BC, Stein, GS, Ito, Y, van Wijnen, AJ, Bae, SC

Cancer Res. 2009
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