MDM2 polyubiquitinates RUNX3

Stable Identifier
R-HSA-8952382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MDM2 polyubiquitinates RUNX3 on lysine residues K94 and K148. MDM-mediated ubiquitination of RUNX3 is inhibited by p14-ARF (Chi et al. 2009).

Literature References
PubMed ID Title Journal Year
19808967 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Chi, XZ, Kim, J, Lee, YH, Lee, JW, Lee, KS, Wee, H, Kim, WJ, Park, WY, Oh, BC, Stein, GS, Ito, Y, van Wijnen, AJ, Bae, SC

Cancer Res. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created